IDH2R140Q-IN-2

SI-7371

IDH2R140Q-IN-2, >98% (HPLC)

CAS No. : [2749568-16-7]

IUPAC Name : 1-(4,6-bis((3-(Trifluoromethyl)phenyl)amino)-1,3,5-triazin-2-yl)pyrrolidin-3-ol

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a highly potent and selective IDH2‑R140Q inhibitor, showing IC₅₀ = 29 nM and >490‑fold selectivity over wild‑type IDH2. It strongly suppresses D2HG production (IC₅₀= 10 nM) and induces differentiation in TF‑1/IDH2‑R140Q cells. The compound displays excellent PK, including 90.3% oral bioavailability and a 6.4 h half‑life. In TF‑1/IDH2‑R140Q xenograft mice, it (25 mg/kg, oral) effectively reduces tumor D2HG levels and shows minimal hERG liability, supporting its promise as an AML therapeutic candidate.

References : Wei Q. et al.: J. Med. Chem., 66(18), 12894-12910, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.