IDO1 inhibitor

SI-7875

IDO1 inhibitor, >98% (HPLC)

IUPAC Name : (E)-(4-((3,4-Difluorophenyl)sulfonyl)piperazin-1-yl)(4-(hydroxyimino)-7-methoxy-4H-chromen-2-yl)methanone

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This chromone‑oxime IDO1 inhibitor bearing a piperazine sulfonamide shows sub‑micromolar potency (hIDO1 IC₅₀ = 0.64 µM; HeLa IC₅₀ = 1.04 µM) and binds directly to IDO1, coordinating the heme iron and inducing a characteristic Soret shift (403 → 421 nm). It is non‑cytotoxic at active concentrations and demonstrates strong antitumor efficacy with low toxicity in CT26 mouse models, outperforming 1‑MT and IDO5L, highlighting its promise as a next‑generation IDO1‑targeted anticancer lead.

References : Wang K. et al.: European Journal of Medicinal Chemistry, Volume 254, 115349, 5 June 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.