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Ifenprodil tartrate

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SI-6124

Ifenprodil tartrate, >98% (HPLC)

CAS No. : [23210-58-4]

Synonyms : NP-120 tartrate; RC-61-91 tartrate

IUPAC Name : 4-(2-(4-Benzylpiperidin-1-yl)-1-hydroxypropyl)phenol hemi((2R,3R)-2,3-dihydroxysuccinate)

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Chemical Properites
Mol. Formula :
C21H27NO2 • 05C4H6O6
Mol. Weight :
400.5
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Ifenprodil tartrate is a noncompetitive NMDA receptor antagonist with marked preference for NR2B‑containing receptors (IC50 = 0.34 µM) relative to NR2A (IC50 = 146 µM). It also blocks α1‑adrenergic receptors and inhibits GIRK (Kir3) channels, reducing basal inward currents. Alongside its neuroprotective, anticonvulsant, and antinociceptive actions, Ifenprodil tartrate inhibits A/H1N1 replication (EC50 = 6.6 µM). It is widely used in studies of cerebrovascular dysfunction and peripheral arterial obliterative disease.

References : Williams K. et al.: Mol. Pharmacol., 44(4), 851-9, 1993; Kobayashi T. et al.: Neuropsychopharmacology, 31(3),516-24, 2006; Chen Y. W. et al.: Pharmacol. Rep., 68(2),357-62, 2016; Jang Y. et al.: Viruses, 12(5), 581, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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