Imipramine-d4

SL-8330

Imipramine-d4, >98%

CAS No. : [773801-61-9]

IUPAC Name : 3-(10,11-Dihydro-5H-dibenzo[b,f]azepin-5-yl-10,10,11,11-d4)-N,N-dimethylpropan-1-amine

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a deuterium labelled version of Imipramine, which is an orally active, tertiary amine tricyclic antidepressant. It acts as a Fascin1 inhibitor with antitumor properties. Additionally, imipramine inhibits the serotonin transporter, demonstrating an IC50 value of 32 nM. The compound stimulates autophagy in U-87MG glioma cells and induces apoptosis in HL-60 cells. Imipramine also exhibits neuroprotective and immunomodulatory effects.

References : Alburquerque-Gonzalez B. et al.: Exp Mol Med., 52(2), 281-292, 2020; Jeon S. H. et al.: Biochem Biophys Res Commun., 413(2), 311-7, 2011; Xia Z. et al.: J. Biochem Mol Toxicol., 13(6), 338-47, 1999; Ramirez K. et al.: Brain Behav Immun., 46, 212-20, 2015; Balkovetz D. F. et al.: J. Biol Chem., 264(4), 2195-8, 1989.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.