INCB-086550

SI-7973

INCB-086550, >98% (HPLC)

CAS No. : [2230911-59-6]

Synonyms : PD-1/PD-L1-IN-8

IUPAC Name : (R)-1-((7-Cyano-2-(3'-((3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-yl)amino)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : INCB-086550 is an orally active PD‑L1 inhibitor with low‑nanomolar potency across human and preclinical species. It promotes PD‑L1 dimerization and drives its internalization and nuclear trafficking, thereby modulating PD‑1/PD‑L1 immune‑checkpoint signaling. These properties support its use in diverse cancer research models.

References : Koblish H. K. et al.: Cancer Discov., 12(6), 1482-1499, 2022 .

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.