Indirubin-3'-monoxime

SI-7769

Indirubin-3'-monoxime, >98% (HPLC)

CAS No. : [160807-49-8]

Synonyms : Indirubin-3'-oxime

IUPAC Name : (2E,3E)-3-(Hydroxyimino)-[2,3'-biindolinylidene]-2'-one

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Applications : Indirubin‑3′‑monoxime exhibits strong inhibition of GSK‑3β (IC₅₀ = 22 nM) and weaker inhibition of 5‑lipoxygenase (IC₅₀= 7.8–10 µM). It also targets CDK5/p25 and CDK1/cyclin B with IC₅₀ values of 100 nM and 180 nM, making it a versatile tool compound for studying kinase‑regulated signaling pathways.M.

References : Leclerc S. et al.: J. Biol. Chem., 276(1), 251-60, 2001. Sharma S. et al.: Biochem Biophys. Res. Commun., 452(4), 1009-15, 2014; Blazevic T. et al.: Cardiovasc Res., 101(3), 522-32, 2014; Cao Z. et al.: J. Med. Chem.,
64(20), 15280-15296, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.