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Infigratinib phosphate

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SI-6725

Infigratinib phosphate, >98% (HPLC)

CAS No. : [1310746-10-1]

Synonyms : BGJ-398 phosphate; NVP-BGJ-398 phosphate

IUPAC Name : 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea phosphate

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Chemical Properites
Mol. Formula :
C26H31Cl2N7O3 • H3PO4
Mol. Weight :
658.47
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Infigratinib phosphate is the phosphate prodrug of infigratinib, a low‑nanomolar FGFR inhibitor with strong activity against FGFR1–3 and reduced potency toward FGFR4 (IC50= 60 nM). It serves as a valuable tool for investigating FGFR‑dependent tumor biology and resistance mechanisms.

References : Guagnano V. et al.: J. Med. Chem., 54(20), 7066-83, 2011; Konecny G. E. et al.: Mol. Cancer Ther., 12(5), 632-42, 2013.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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