Iptacopan

SL-10750

Iptacopan, >98%

CAS No. : [1644670-37-0]

Synonyms : LNP-023

IUPAC Name : 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Iptacopan is a highly selective, orally active inhibitor of factor B, with an IC50 of 10 nM and a KD of 7.9 nM. By acting early in the complement cascade, it helps prevent the destruction (hemolysis) of red blood cells in PNH and protects kidney cells from damage in IgAN and C3G. It is useful for studying diseases mediated by the complement system, especially paroxysmal nocturnal hemoglobinuria (PNH), primary immunoglobulin A nephropathy (IgAN), and complement 3 glomerulopathy (C3G).

References : Dimitrios C. M. et al.: Proc Natl Acad Sci U S A. 116(16), 7926-7931, 2019; Nello M. et al.: J. Med Chem., 63(11), 5697-5722, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.