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Irbesartan oxime

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Irbesartan oxime, >98%

CAS No. : [2757965-00-5]

Synonyms : Irbesartan oxime impurity

IUPAC Name : 3-((2'-(1H-Tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-(1-(hydroxyimino)butyl)-1,3-diazaspiro[4.4]non-1-en-4-one

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Chemical Properites
Mol. Formula :
C25H27N7O2
Mol. Weight :
457.54
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Irbesartan, which is a highly potent and specific angiotensin II type 1 (AT1) receptor antagonist. It is used to treat high blood pressure, heart failure, and diabetic kidney disease.

References : Bernhart C. A et al.: J. Med Chem., 36(22), 3371-3380, 1993; Kawano H. et al.: Hypertension, 35, 273-279, 2000; Schupp M. et al.: Circulation, 109(17), 2054-2057, 2004; Ruiz E. et al.: Eur J. Pharmacol., 567(3), 231-239, 2007; Dalla Libera L. et al.: Circulation, 103(17), 2195-2200, 2001.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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