Irinotecan-d10 hydrochloride

SI-6472

Irinotecan-d₁₀ hydrochloride, >98% (HPLC)

CAS No. : [718612-62-5]

Synonyms : (+)-Irinotecan-d₁₀ hydrochloride; CPT-11-_d10 hydrochloride; VAL-413-d₁₀

IUPAC Name : (S)-4,11-Diethyl-4-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl [1,4'-bipiperidine]-1'-carboxylate-d₁₀ hydrochloride

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : Irinotecan‑d₁₀ hydrochloride is a deuterated analog of Irinotecan that inhibits topoisomerase I by trapping the enzyme–DNA cleavage complex and preventing religation of single‑strand breaks, leading to replication‑dependent cytotoxicity.

References : Russak E. M. et al.: Ann. Pharmacother., 53(2), 211-216, 2019; Morales C. et al.: J. Neurooncol., 56(3), 219-26, 2002; Pavillard V. et al.: Cancer Chemother. Pharmacol., 49(4), 329-35, 2002; Allegrini G. et al.: Cancer Chemother. Pharmacol., 53(3), 261-6, 2004; Cruz F. S. D. et al.: Genome Med., 8(1), 116, 2016; Huang M. Y. et al.: Apoptosis., 21(2), 130-42, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.