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Isavuconazole oxazine impurity

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Isavuconazole oxazine impurity, >98%

CAS No. : [2734004-61-4]

Synonyms : Isavuconazole impurity 33

IUPAC Name : 1-Methyl-1,4-dihydro-2H-pyrido[2,3-d][1,3]oxazin-2-one

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In Stock  Estimated to ship on 20 September 2026
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Chemical Properites
Mol. Formula :
C8H8N2O2
Mol. Weight :
164.16
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Isavuconazole, which is a triazole proagent with antifungal activity against yeasts, molds, and dimorphic fungi. Isavuconazole inhibits ergosterol biosynthesis, which disrupts fungal membrane structure and function. Isavuconazole also acts as a moderate inhibitor of CYP3A4.

References : Seifert H. et al.: Antimicrob Agents Chemother., 51(5), 1818-21, 2007; Steinmann J. et al.: Antimicrob Agents Chemother., 60(11), 6890-6891, 2016; Donnelley M. A. et al.: Infect Drug Resist., 9, 79-86, 2016; Box H. et al.: Antimicrob Agents Chemother., 60(1), 278-87, 2015; Livermore J. et al.: Expert Opin Drug Metab Toxicol., 8(6), 759-65, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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