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Isavuconazonium chloride (enantiomer)

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Isavuconazonium chloride (enantiomer), >98%

IUPAC Name : 1-((2S,3S)-3-(4-(4-Cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl)-1H-1,2,4-triazol-4-ium chloride hydrochloride

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Chemical Properites
Mol. Formula :
C35H35ClF2N8O5S • HCl
Mol. Weight :
789.68
Appearance :
Pale yellow solid (hygroscopic)
Melting Point :
Not available
Solubility :
H2O
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an enantiomer of Isavuconazonium chloride, which is a precursor of the triazole antifungal active molecule Isavuconazole.

References : Seifert H. et al.: Antimicrob Agents Chemother., 51(5), 1818-21, 2007; Steinmann J. et al.: Antimicrob Agents Chemother., 60(11), 6890-6891, 2016; Donnelley M. A. et al.: Infect Drug Resist., 9, 79-86, 2016; Box H. et al.: Antimicrob Agents Chemother., 60(1), 278-87, 2015; Livermore J. et al.: Expert Opin Drug Metab Toxicol., 8(6), 759-65, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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