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Islatravir

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SI-5878

Islatravir, >98% (HPLC)

CAS No. : [865363-93-5]

MDL No. : MFCD28502143

Synonyms : MK-8591

IUPAC Name : (2R,3R,5R)-5-(6-Amino-2-fluoro-9H-purin-9-yl)-2-ethynyl-2-(hydroxymethyl)tetrahydrofuran-3-ol; 4'-Ethynyl-2-fluoro-2'-deoxyadenosine

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Chemical Properites
Mol. Formula :
C12H12FN5O3
Mol. Weight :
293.26
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Islatravir is a potent anti-HIV-1 agent, acting as a nucleoside reverse transcriptase (NRT) inhibitor, with EC50s of 0.068 nM, 3.1 nM and 0.15 nM for HIV-1 (WT), HIV-1 (M184V), HIV-1 (MDR), respectively.

References : Ohrui H. et al.: Chem Rec., 6(3), 133-43, 2006.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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