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ITH-15004

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SI-6169

ITH-15004, >98% (HPLC)

CAS No. : [2600675-12-3]

IUPAC Name : 2-(6-Chloro-9H-purin-9-yl)-1-(2,4-dichlorophenyl)ethan-1-one

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Chemical Properites
Mol. Formula :
C13H7Cl3N4O
Mol. Weight :
341.58
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : ITH-15004 is a brain‑penetrant P2X7 receptor antagonist that blocks P2X7‑mediated neuroinflammatory signaling. Its CNS activity makes it valuable for probing P2X7‑linked mechanisms in models of neurodegeneration.

References : Calzaferri F. et al.: J. Med .Chem., 64(4), 2272-2290, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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