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Itopride-d6 hydrochloride

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Itopride-d6 hydrochloride, 98% (CP)

Isotopic Purity : 99 atom % D

MDL No. : MFCD28386054

Related CAS No. : [122892-31-3] of the unlabelled compound

Synonyms : HSR-803-d6

IUPAC Name : N-(4-(2-(Dimethylamino)ethoxy)benzyl)-3,4-bis(methoxy-d3)benzamide hydrochloride

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Chemical Properites
Mol. Formula :
C20H20D6N2O4. HCl
Mol. Weight :
400.93
Appearance :
White solid
Melting Point :
104-107oC (free base)
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version of Itopride hydrochloride, which is a dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. It enhances gastric motility through both antidopaminergic and anti-acetylcholinesterase mechanisms, and may be used as a gastrointestinal prokinetic agent. Itopride is also used in research related to gastro-esophageal reflux disease (GERD).

References : Iwanaga Y. et al.: Gastroenterology 99(2), 401-8, 1990; Kim Y. S. et al.: World J. Gastroenterol., 11(27), 4210-4, 2005; Hyun C. L. et al.: Yonsei Med J. 49(3), 472-8, 2008; Kenjiro M. et al.: Biol. Pharm. Bull., 31(10):1917-22, 2008.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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