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Ivabradine impurity B

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Ivabradine impurity B, >98%

IUPAC Name : 3-(3-(((3,4-Dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxydecahydro-2H-benzo[d]azepin-2-one

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Chemical Properites
Mol. Formula :
C27H42N2O5 . C4H6O6
Mol. Weight :
624.73
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Ivabradine, which is an orally bioavailable, hyperpolarization-activated, cyclic nucleotide-gated (HCN) channel blocker. Ivabradine is used for the symptomatic management of stable heart-related chest pain and heart failure not fully managed by beta blockers.

References : Thollon C. et al.: Br. J. Pharmacol.,112(1), 37-42, 1994; Fang Y. et al.: J. Cardiovasc Pharmacol., 59(3), 260-7, 2012; Kroller-Schon S. et al.: Basic Res Cardiol.,106(6), 1147-58, 2011.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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