JAK1/TYK2-IN-3

SI-6932

JAK1/TYK2-IN-3, >98% (HPLC)

CAS No. : [2734918-37-5]

IUPAC Name : 8-(2-((1-(Difluoromethyl)-1H-pyrazol-4-yl)amino)-5-methylpyrimidin-4-yl)-2,8-diazaspiro[4.5]decan-1-one

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This compound shows excellent potency on TYK2 and JAK1 (IC₅₀ = 6 and 37 nM) with >23‑fold selectivity over JAK2. It also demonstrates strong metabolic stability and superior anti‑inflammatory efficacy to tofacitinib in acute ulcerative colitis models. Its activity is driven by modulation of TYK2/JAK1‑regulated genes and the formation of Th1, Th2, and Th17 cells. Overall, it is a promising selective dual TYK2/JAK inhibitor suitable for advancement as a clinical candidate.

References : Yang T. et al.: J. Med. Chem., 65(4), 3151-3172, 2022.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.