JET-209

SI-7558

JET-209, >98% (HPLC)

CAS No. : [3033714-58-5]

IUPAC Name : 5-(8-(5-Acetyl-1-(tetrahydro-2H-pyran-4-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl)isoquinolin-3-yl)-N-(1-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)piperidin-4-yl)picolinamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : JET‑209 potently degrades CBP and p300 at sub‑nanomolar concentrations and shows strong antitumor efficacy in acute leukemia models. It inhibits proliferation across diverse leukemia cell lines and significantly reduces tumor burden in vivo, making it well suited for studying CBP/p300‑regulated leukemogenic mechanisms.

References : Thomas J. E. et al.: J. Med. Chem., 66(12), 8178-8199, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.