JNJ-38877605

SI-8051

JNJ-38877605, >98% (HPLC)

CAS No. : [943540-75-8]

IUPAC Name : 6-(Difluoro(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl)quinoline

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
250MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
500MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : JNJ‑38877605 is a potent, orally active ATP‑competitive c‑MET inhibitor (IC₅₀= 4 nM) with ~600‑fold selectivity over 200 kinases. It blocks c‑MET phosphorylation and impacts lipid accumulation, making it a valuable tool for investigating MET‑dependent tumor biology and metabolic disease mechanisms.

References : De Bacco F. et al.: J. Natl. Cancer Inst., 103(8), 645-661, 2011; Torti D. et al.: Int. J. Cancer, 130(6), 1357-1366, 2012; Wang A. et al.: Cell Commun. Signal., 20(1), 16, 2022; Park Y. K. et al.: Int. J. Mol. Sci., 24(9), 8086, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.