JNJ-42253432

SI-6527

JNJ-42253432, >98% (HPLC)

CAS No. : [1428327-35-8]

IUPAC Name : 2-Methyl-N-((1-(4-phenylpiperazin-1-yl)cyclohexyl)methyl)-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : JNJ‑42253432 antagonizes the P2X7 receptor with high affinity (pK_i = 9.1 rat; 7.9 human) and demonstrates robust CNS penetration and oral activity. These properties support its use in studies of P2X7‑driven neuroinflammation and CNS pathology.

References : Brian Lord. et al.: J. Pharmacol. Exp. Ther., 351(3), 628-41, 2014.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.