JNJ-54717793

SI-6613

JNJ-54717793, >98% (HPLC)

CAS No. : [1628843-99-1]

IUPAC Name : (3-Fluoro-2-(pyrimidin-2-yl)phenyl)((1S,2R,4R)-2-((5-(trifluoromethyl)pyrazin-2-yl)amino)-7-azabicyclo[2.2.1]heptan-7-yl)methanone

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : JNJ‑54717793 selectively targets the orexin‑1 receptor with high affinity (Ki = 16 nM) and shows minimal activity at OX2R (Ki = 700 nM). As a brain‑penetrant, orally active antagonist with a plasma EC₅₀ of 85 ng/mL, it is widely used to probe OX1R‑driven mechanisms in anxiety models.

References : Préville C. et al.: ACS. Med. Chem. Lett., 11(10), 2002-2009, 2020; Bonaventure P. et al. : Front. Pharmacol., 8, 357, 2017.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.