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JNJ-63533054

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SI-6756

JNJ-63533054, >98% (HPLC)

CAS No. : [1802326-66-4]

IUPAC Name : (S)-3-Chloro-N-(2-oxo-2-((1-phenylethyl)amino)ethyl)benzamide

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Chemical Properites
Mol. Formula :
C17H17ClN2O2
Mol. Weight :
316.79
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : JNJ‑63533054 activates human GPR139 with nanomolar potency (EC50 = 16 nM) and exhibits strong selectivity relative to other receptor families. Its oral bioavailability and blood–brain barrier permeability make it a valuable tool for probing central GPR139 signaling.

References : Liu. C. et al.: Mol. Pharmacol., 88(5), 911-25, 2015; Dvorak C. A. et al.: ACS Med. Chem. Lett., 6(9), 1015-8, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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