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JNJ-67569762

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SI-6788

JNJ-67569762, >98% (HPLC)

CAS No. : [2380313-26-6]

IUPAC Name : N-(3-((2R,5S)-6-Amino-5-(ethylsulfonyl)-2-(fluoromethyl)-5-methyl-2,3,4,5-tetrahydropyridin-2-yl)-4-fluorophenyl)-2,2-difluoro-[1,3]dioxolo[4,5-c]pyridine-6-carboxamide

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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250MGRequest A Quote
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C22H22F4N4O5S
Mol. Weight :
530.49
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : JNJ‑67569762 selectively targets the S3 pocket of BACE1 and inhibits the enzyme with nanomolar potency (IC50 = 2.7 nM), making it a valuable tool for investigating APP cleavage and Alzheimer’s‑related mechanisms.

References : Rombouts F. J. R. et al.: J. Med. Chem., 64(19), 14175-14191, 2021.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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