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JNK-IN-8

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SI-7746

JNK-IN-8, >98% (HPLC)

CAS No. : [1410880-22-6]

Synonyms : JNK inhibitor XVI

IUPAC Name : (E)-3-(4-(Bimethylamino)but-2-enamido)-N-(3-methyl-4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide

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Chemical Properites
Mol. Formula :
C29H29N7O2
Mol. Weight :
507.6
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This potently inhibits JNK1, JNK2, and JNK3 with IC50 values of 4.7 nM, 18.7 nM, and 1 nM, respectively. Its high selectivity and strong target engagement make it a valuable probe for dissecting JNK‑regulated cellular processes.

References : Zhang T. et al.: Chem. Biol., 19(1), 140-54, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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