JR1-157

SI-7239

JR1-157, >98% (HPLC)

CAS No. : [2446964-31-2]

Synonyms : NSC-807353

IUPAC Name : N-(5-Chloroquinolin-8-yl)-5-((5-(diethylamino)pentan-2-yl)amino)pyrazine-2-carboxamide

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : JR1‑157 is a selective σ₂ receptor ligand (K_i = 47 nM) from the quinolyl‑pyrazinamide series, showing sub‑micromolar potency in pancreatic cancer cells. It is water‑soluble, metabolically stable, and orally bioavailable (60%), demonstrating in vivo antitumor efficacy without evident toxicity. JR1‑157’s cytotoxicity is copper‑dependent and it increases LC3B expression, supporting its advancement as a σ₂R‑targeted lead for pancreatic cancer.

References : Roy J. et al.: J. Med. Chem., 66(3), 1990-2019, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.