KHK inhibitor

SI-7383

KHK inhibitor, >98% (HPLC)

IUPAC Name : 3-((S)-1-(2-((S)-2-Methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)pyrrolidin-3-yl)propanoic acid

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : This is a potent ketohexokinase (KHK) inhibitor that shows stronger in vivo KHK inhibition than PF‑06835919 and achieves higher liver exposure. Its favorable ADME and PK profile supports its advancement as a promising clinical candidate for treating fructose‑driven metabolic disorders such as NAFLD, obesity, and insulin resistance.

References : Zhu G. et al.: J. Med. Chem., 66(19), 13501-13515, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.