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KRN-633-d6

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SL-362

KRN-633-d6, >98% (CP)

Isotopic Purity : 99 atom % D

MDL No. : MFCD28343971

Related CAS No. : [286370-15-8] of the unlabelled compound

Synonyms : N-​[2-​Chloro-​4-​[(6,​7-​dimethoxy-d6-​4-​quinazolinyl)oxy]phenyl]-​N'-​propyl-​urea

IUPAC Name : 1-(4-((6,7-Bis(methoxy-d3)quinazolin-4-yl)oxy)-2-chlorophenyl)-3-propylurea

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Chemical Properites
Mol. Formula :
C20H15D6ClN4O4
Mol. Weight :
422.90
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Deuterium labelled analog of KRN-633, a new quinazoline urea derivative, strongly inhibits VEGFR1, VEGFR2 and VEGFR3 receptors with IC50 values of 170 nM, 160 nM and 125 nM respectively.

References : Nakamura K. et. al.: Molecular Cancer Therapeutics, 3(12),1639, 2004.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term storage.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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