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KU-60019

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SI-7554

KU-60019, >98% (HPLC)

CAS No. : [925701-46-8]

IUPAC Name : 2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide

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Chemical Properites
Mol. Formula :
C30H33N3O5S
Mol. Weight :
547.67
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : KU‑60019 selectively inhibits ATM with nanomolar potency (IC50 = 6.3 nM) and is commonly employed to study ATM‑mediated DNA repair, checkpoint signaling, and cellular sensitivity to radiation or genotoxic stress.

References : Golding S. E. et al.: Mol. Cancer Ther., 8(10), 2894-902, 2009; Mc Cabe N. et al.: Cancer Res., 75(11), 2159-65, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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