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KW-2449

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SI-8001

KW-2449, >98% (HPLC)

CAS No. : [1000669-72-6]

IUPAC Name : (E)-(4-(2-(1H-Indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone

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25MGRequest A Quote
Back Order  Estimated to ship on 04 October 2026
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250MGRequest A Quote
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Back Order  Estimated to ship on 04 October 2026
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Chemical Properites
Mol. Formula :
C20H20N4O
Mol. Weight :
332.41
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : KW‑2449 inhibits FLT3, ABL, ABL^T315I, and Aurora kinase with low‑nanomolar potency. Its activity against the ABL^T315I mutant highlights its relevance for investigating resistance mechanisms in kinase‑driven cancers.

References : Shiotsu Y. et al.: Blood, 114(8), 1607-17, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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