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KW-2450 tosylate

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SI-6448

KW-2450 tosylate, >98% (HPLC)

CAS No. : [1360433-93-7]

IUPAC Name : (E)-N-(2-(2-(1H-Indazol-3-yl)vinyl)-5-((4-(2-hydroxyacetyl)piperazin-1-yl)methyl)phenyl)-3-methylthiophene-2-carboxamide 4-methylbenzenesulfonate

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Chemical Properites
Mol. Formula :
C28H29N5O3S • C7H8O3S
Mol. Weight :
687.83
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : KW‑2450 tosylate inhibits Aurora A/B and IGF‑1R/IR signaling, leading to apoptosis and reduced viability of TNBC cells. It displays notable anticancer activity in TNBC models and serves as a useful tool for evaluating multikinase‑driven tumor biology.

References : Kai K. et al.: Mol. Cancer Ther., 14(12), 2687-99, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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