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L-165041

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SI-7335

L-165041, >98% (HPLC)

CAS No. : [79558-09-1]

IUPAC Name : 2-(4-(3-(4-Acetyl-3-hydroxy-2-propylphenoxy)propoxy)phenoxy)acetic acid

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Chemical Properites
Mol. Formula :
C22H26O7
Mol. Weight :
402.44
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : L‑165041 selectively activates PPARδ with nanomolar affinity (Ki= 6 nM) and shows substantially weaker binding to PPARγ (~730 nM). In NIH‑PPARδ cells, it induces adipocyte differentiation, supporting its use in studies of PPARδ‑mediated metabolic regulation.

References : Berger J. et al.: J. Biol Chem., 274(10), 6718-25, 1999; Jin-Hee P. et al.: Journal of Cellular Biochemistry 113(6), 1947-1954, 2012; Hyun-Joung L. et al.: European Journal of Pharmacology, 622(1-3), 45-51, 2019; Hyun-Joung L. et al.: 202(2), 446-454, 2009.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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