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L-655708

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SI-7078

L-655708, >98% (HPLC)

CAS No. : [130477-52-0]

IUPAC Name : Ethyl (S)-7-methoxy-9-oxo-11,12,13,13a-tetrahydro-9H-benzo[e]imidazo[5,1-c]pyrrolo[1,2-a][1,4]diazepine-1-carboxylate

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Chemical Properites
Mol. Formula :
C18H19N3O4
Mol. Weight :
341.37
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : L‑655708 is a highly potent and α5‑selective inverse agonist at the GABAA receptor benzodiazepine site, exhibiting a binding affinity of 0.45 nM. Its strong subtype selectivity makes it a valuable tool for probing α5‑mediated inhibitory neurotransmission.

References : Saab B. J. et al.: Anesthesiology, 113(5), 1061-1071, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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