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Lanabecestat

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SI-5422

Lanabecestat, >98% (HPLC)

CAS No. : [1383982-64-6]

MDL No. : MFCD30747858

Synonyms : AZD-3293; LY3314814

IUPAC Name : (1s,1'R,4S)-4-Methoxy-5''-methyl-6'-(5-(prop-1-yn-1-yl)pyridin-3-yl)-3'H-dispiro[cyclohexane-1,2'-indene-1',2''-imidazol]-4''-amine

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Chemical Properites
Mol. Formula :
C26H28N4O
Mol. Weight :
412.54
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Lanabecestat is a potent, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. Lanabecestat is used for the research of Alzheimer's disease.

References : Eketjall S. et al.: J. Alzheimers Dis., 50(4), 1109-23, 2016.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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