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Lapatinib impurity F

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Lapatinib impurity F, >98%

CAS No. : [320337-48-2]

IUPAC Name : (5-(4-((3-Chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl)furan-2-yl)methanol

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Chemical Properites
Mol. Formula :
C26H19ClFN3O3
Mol. Weight :
475.9
Appearance :
Yellow solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Lapatinib, which is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains. Lapatinib is an antineoplastic agent, and used for the treatment of advanced or metastatic HER-positive breast cancer.

References : O'Neill F. et al.: Mol Cancer. Jun 18,11(1), 41, 2012; Karajannis M. A. et al.: Neuro Oncol. Sep 14(9), 1163, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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