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Lapatinib impurity I

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Lapatinib impurity I, >98%

CAS No. : [633370-23-7]

IUPAC Name : N-(4-((3-Fluorobenzyl)oxy)phenyl)-6-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)quinazolin-4-amine

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Chemical Properites
Mol. Formula :
C29H27FN4O4S
Mol. Weight :
546.62
Appearance :
Yellow solid
Melting Point :
Not available
Solubility :
MeOH
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Lapatinib, which is a potent inhibitor of the ErbB-2 and EGFR tyrosine kinase domains. Lapatinib is an antineoplastic agent, and used for the treatment of advanced or metastatic HER-positive breast cancer.

References : O'Neill F. et al.: Mol Cancer. Jun 18,11(1), 41, 2012; Karajannis M. A. et al.: Neuro Oncol. Sep 14(9), 1163, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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