LC-MB 12

SI-7980

LC-MB 12, >98% (HPLC)

CAS No. : [2828438-38-4]

IUPAC Name : 3-(2,6-Dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-(1-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)piperidine-4-carbonyl)piperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
10MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
25MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
50MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
100MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026

Applications : LC‑MB12 is an oral FGFR2‑targeting PROTAC composed of BGJ-398, a linker, and a CRBN ligand. It induces FGFR2 degradation with a DC₅₀ of 11.8 nM, blocks FGFR2‑dependent signaling in gastric cancer cells, and shows measurable antitumor effects.

References : Ma L. et al.: J. Med. Chem., 66(11), 7438-7453, 2023.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.