LDN-192960 dihydrochloride

SI-7465

LDN-192960 dihydrochloride, >98% (HPLC)

CAS No. : [2309172-48-1]

IUPAC Name : 3-((2,7-Dimethoxyacridin-9-yl)thio)propan-1-amine dihydrochloride

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5MG	Request A Quote		Back Order	Estimated to ship on 04 October 2026
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Applications : LDN‑209929 dihydrochloride selectively inhibits Haspin with nanomolar potency (IC₅₀ = 55 nM) and shows markedly reduced activity toward DYRK2 (IC₅₀ = 9.9 µM; ~180‑fold selectivity). As an optimized derivative of LDN‑192960, it is well suited for mechanistic studies of Haspin‑mediated chromosomal dynamics.

References : Cuny G. D. et al.: Bioorg. Med. Chem. Lett., 20(12), 3491-4, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.