Lenacapavir impurity 3 (mixture of atropisomers)

SL-10830

Lenacapavir impurity 3 (mixture of atropisomers), >98%

CAS No. : [3053923-46-6]

IUPAC Name : (S)-N-(7-(2-(1-Amino-2-(3,5-difluorophenyl)ethyl)-6-(3-methyl-3-(methylsulfonyl)but-1-yn-1-yl)pyridin-3-yl)-4-chloro-1-(2,2,2-trifluoroethyl)-1H-indazol-3-yl)methanesulfonamide

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Applications : This compound is identified as an impurity associated with Lenacapavir. It is a unique, long-acting HIV-1 capsid inhibitor approved for treating multi-drug-resistant HIV and is highly effective as a twice-yearly injection for HIV prevention (PrEP).

References : Singh K. et al.: Front Microbiol., 10, 1227, 2019; John O. L. et al.: Nature, 584(7822), 614-61, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.