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Lenacapavir penteneyne impurity

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Lenacapavir penteneyne impurity, >98%

CAS No. : [3025145-45-0]

Synonyms : Lenacapavir impurity 6 (mixture of atropisomers); Lenacapavir double bond impurity

IUPAC Name : N-((S)-1-(3-(4-Chloro-3-(methylsulfonamido)-1-(2,2,2-trifluoroethyl)-1H-indazol-7-yl)-6-(3-methylbut-3-en-1-yn-1-yl)pyridin-2-yl)-2-(3,5-difluorophenyl)ethyl)-2-((3bS,4aR)-5,5-difluoro-3-(trifluoromethyl)-3b,4,4a,5-tetrahydro-1H-cyclopropa[3,4]cyclopenta[1,2-c]pyrazol-1-yl)acetamide

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Chemical Properites
Mol. Formula :
C38H28ClF10N7O3S
Mol. Weight :
888.18
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
Acetonitrile
For Laboratory research use only, not for drug, household or other uses.

Applications : This compound is identified as an impurity associated with Lenacapavir. It is a unique, long-acting HIV-1 capsid inhibitor approved for treating multi-drug-resistant HIV and is highly effective as a twice-yearly injection for HIV prevention (PrEP).

References : Singh K. et al.: Front Microbiol., 10, 1227, 2019; John O. L. et al.: Nature, 584(7822), 614-61, 2020.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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