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Lenalidomide open chain Amadori impurity

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Lenalidomide open chain Amadori impurity, >98%

IUPAC Name : 3-(1-oxo-4-(((3R,4S,5S)-3,5,6-Trihydroxy-2-oxo-4-(((2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexyl)amino)isoindolin-2-yl)piperidine-2,6-dione

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Chemical Properites
Mol. Formula :
C25H33N3O13
Mol. Weight :
583.55
Appearance :
Off-white solid
Melting Point :
Not available
Solubility :
H2O
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of Lenalidomide, which is an immunomodulator and an antiangiogenic agent for the treatment of multiple myeloma (MM) and myelodysplastic syndromes (MDS).

References : Kotla V. et al.: J. Hematol Oncol., 2, 36, Aug 12, 2009: Lopez-Girona A. et al.: Leukemia 26(11), 2326-2335, 2012; Rozewski D. M. et al.: AAPS J. 14(4), 872-882, 2012; Minzel W. et al.: Cell 175(1), 171-185. 2018.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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