Letrozole EP impurity A

SL-6485

Letrozole EP impurity A, >98%

CAS No. : [112809-52-6]

Synonyms : Isoletrozole

IUPAC Name : 4,4'-((4H-1,2,4-Triazol-4-yl)methylene)dibenzonitrile

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Applications : This is an impurity of Letrozole (Letrozole EP impurity A), which is a third generation inhibitor of aromatase, used in the treatment of hormonally-responsive breast cancer after surgery.

References : Haynes B. P. et al.: J. Steroid Biochem Mol Biol., 87(1), 35-45, 2003; Bhatnagar A. S. et al.: J. Steroid Biochem Mol Biol., 37(6), 1021-1027, 1990; Mitropoulou T. N. et al.: Int. J. Cancer., 104(2), 155-160, 2003; Dellapasqua S. et al.: Expert Opin Drug Metab Toxicol., 6(2), 251-259, 2010; Lee K. et al.: Int J Cancer., 62(3), 297-302, 1995; Steele R. E. et al.: Steroids, 50(1-3), 147-161, 1987.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.