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Levoleucovorin

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SL-8450

Levoleucovorin, >98%

CAS No. : [68538-85-2]

Synonyms : Levofolinic acid; Levofolene

IUPAC Name : (4-((((S)-2-Amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamic acid

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Chemical Properites
Mol. Formula :
C20H23N7O7
Mol. Weight :
473.45
Appearance :
Pale yellow solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Levoleucovorin is the pharmacologically active levoisomer of racemic Leucovorin. It can be used as a rescue agent following high-dose methotrexate therapy. Additionally, Levoleucovorin is used in combination with Fluorouracil for the treatment of advanced metastatic colorectal cancer.

References : Chuang V. T. et al.: Ann Pharmacother., 46(10), 1349-57, 2012.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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