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Levoleucovorin calcium

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SI-6700

Levoleucovorin calcium, >98% (HPLC)

CAS No. : [80433-71-2]

Synonyms : Calcium levofolinate; CL-307782

IUPAC Name : Calcium (4-((((S)-2-amino-5-formyl-4-oxo-1,4,5,6,7,8-hexahydropteridin-6-yl)methyl)amino)benzoyl)-L-glutamate

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Chemical Properites
Mol. Formula :
C20H21CaN7O7
Mol. Weight :
511.51
Appearance :
Solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : Levoleucovorin calcium is the active calcium salt of folinic acid with anti‑tumor properties. It acts as a potent enhancer of 5‑Fluorouracil activity by stabilizing the 5‑FU–thymidylate synthase complex, improving the cytotoxic response in cancer models.

References : Murakami Y. et al.: J. Toxicol. Sci., 23(1), 11-29, 1998.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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