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Levothyroxine EP impurity B

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Levothyroxine EP impurity B, >96%

CAS No. : [1628720-66-0]

Synonyms : 3-Chlorothyroxine

IUPAC Name : (S)-2-Amino-3-(4-(3-chloro-4-hydroxy-5-iodophenoxy)-3,5-diiodophenyl)propanoic acid

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Chemical Properites
Mol. Formula :
C15H11ClI3NO4
Mol. Weight :
685.42
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of L-Thyroxine (Levothyroxine EP impurity B), which is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

References : Arici M. et al.: Endocr J. 65(3), 317, 2018; Corriveau S. et al.: J. Clin Transl Endocrinol. 2(4),144, 2015.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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