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Levothyroxine USB B impurity

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Levothyroxine USB B impurity, >95% (HPLC)

CAS No. : [93647-48-4]

MDL No. : MFCD06797868

Synonyms : 3,5,3’,5’-Tetraiodo thyromandelic acid; T4-Hydroxyacetic acid; Levothyroxine T4-hydroxyacetic acid

IUPAC Name : 2-Hydroxy-2-(4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl)acetic acid

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Chemical Properites
Mol. Formula :
C14H8I4O5
Mol. Weight :
763.83
Appearance :
White to Off-white solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : This is an impurity of L-Thyroxine (Levothyroxine USB B impurity), which is a synthetic hormone in the treatment of hypothyroidism. DIO enzymes convert biologically active thyroid hormone (Triiodothyronine,T3) from L-Thyroxine (T4).

References : Yamauchi K. et al.: J. Biol. Chem., 274, 8460, 1999; Davis P. et al.: J. Endocrinol. Invest., 25, 377, 2002.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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