Lifitegrast impurity 1

SL-10884

Lifitegrast impurity 1, >98%

CAS No. : [1194550-61-2]

Synonyms : 1,1-Dimethylethyl 5,7-dichloro-3,4-dihydro-6-[[[(1S)-1-[[3-(methylsulfonyl)phenyl]methyl]-2-oxo-2-(phenylmethoxy)ethyl]amino]carbonyl]-2(1H)-isoquinolinecarboxylate (ACI); Benzyl (S)-2-[[[2-(tert-butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-yl]carbonyl]amino]-3-[3-(methylsulfonyl)phenyl]propanoate

IUPAC Name : tert-Butyl (S)-6-((1-(benzyloxy)-3-(3-(methylsulfonyl)phenyl)-1-oxopropan-2-yl)carbamoyl)-5,7-dichloro-3,4-dihydroisoquinoline-2(1H)-carboxylate

Price And Availability
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5MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
10MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
25MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
50MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
100MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026

Applications : This is an impurity of Lifitegrast, which is a potent integrin antagonist that blocks ICAM-1 from binding to LFA-1, disrupting T cell-driven inflammation. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM and can be used in dry eye disease research.

References : Perez V. L. et al.: Ocul Surf., 14(2), 207-15, 2016; Sun Y. et al.: J. Ocul Pharmacol Ther., 29(4), 395-402, 2013; Rao V. R. et al.: Invest Ophthalmol Vis Sci., 51(10), 5198-204, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.