Lifitegrast Impurity 2

SL-10885

Lifitegrast Impurity 2, >98%

CAS No. : [1194864-18-0]

Synonyms : Benzyl (S)-2-[[(5,7-dichloro-1,2,3,4-tetrahydroisoquinolin-6-yl)carbonyl]amino]-3-[3- (methylsulfonyl)phenyl]propanoate; N-[(5,7-Dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl)carbonyl]-3- (methylsulfonyl)-L-phenylalanine phenylmethyl ester (ACI)

IUPAC Name : Benzyl (S)-2-(5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

Price And Availability
Pack Size	Price in USD	Add To Shopping Cart	Availability	Shipping Status
5MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
10MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
25MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
50MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
100MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026

Applications : This is an impurity of Lifitegrast, which is a potent integrin antagonist that blocks ICAM-1 from binding to LFA-1, disrupting T cell-driven inflammation. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM and can be used in dry eye disease research.

References : Perez V. L. et al.: Ocul Surf., 14(2), 207-15, 2016; Sun Y. et al.: J. Ocul Pharmacol Ther., 29(4), 395-402, 2013; Rao V. R. et al.: Invest Ophthalmol Vis Sci., 51(10), 5198-204, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.