Lifitegrast (R)-isomer

SL-10883

Lifitegrast (R)-isomer, >98%

CAS No. : [2271299-08-0]

Synonyms : N-[[2-(6-Benzofuranylcarbonyl)-5,7-dichloro-1,2,3,4-tetrahydro-6-isoquinolinyl]carbonyl]-3-(methylsulfonyl)-D-phenylalanine (ACI); (R)-Lifitegrast; Lifitegrast impurity 8

IUPAC Name : (R)-2-(2-(Benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

Price And Availability
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5MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
10MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
25MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
50MG	Request A Quote		In Stock	Estimated to ship on 20 September 2026
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Applications : This is an opposite enantiomer of Lifitegrast, which is a potent integrin antagonist that blocks ICAM-1 from binding to LFA-1, disrupting T cell-driven inflammation. Lifitegrast inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM and can be used in dry eye disease research.

References : Perez V. L. et al.: Ocul Surf., 14(2), 207-15, 2016; Sun Y. et al.: J. Ocul Pharmacol Ther., 29(4), 395-402, 2013; Rao V. R. et al.: Invest Ophthalmol Vis Sci., 51(10), 5198-204, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.