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Lifitegrast sodium

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SL-10880

Lifitegrast sodium, >98%

CAS No. : [1119276-80-0]

Synonyms : SAR 1118 sodium; SHP-606 sodium

IUPAC Name : Sodium (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoate

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Chemical Properites
Mol. Formula :
C29H23Cl2N2NaO7S
Mol. Weight :
637.46
Appearance :
Solid
Melting Point :
Not available
Solubility :
DMSO
For Laboratory research use only, not for drug, household or other uses.

Applications : Lifitegrast sodium is a potent integrin antagonist that blocks ICAM-1 from binding to LFA-1, disrupting T cell-driven inflammation. It inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM and can be used in dry eye disease research.

References : Perez V. L. et al.: Ocul Surf., 14(2), 207-15, 2016; Sun Y. et al.: J. Ocul Pharmacol Ther., 29(4), 395-402, 2013; Rao V. R. et al.: Invest Ophthalmol Vis Sci., 51(10), 5198-204, 2010.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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