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Lisinopril-d5 EP impurity G

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SL-4525

Lisinopril-d5 EP impurity G, >98% (HPLC)

Isotopic Purity : 98 atom % D

CAS No. : [1356847-97-6]

Synonyms : (2S)-1-[(2S)-6-Amino-2-[[(2S)-1-[[[(5S)-5-[[(1S)-1-carboxy-3-(phenyl-d5)propyl]amino]-6-[(2S)-2-carboxypyrrolidin-1-yl]-6-oxohexyl]amino]carbonyl]-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid; Lisinopril-d5 dimer

IUPAC Name : N6-((S)-2-(((S)-6-amino-1-((S)-2-carboxypyrrolidin-1-yl)-1-oxohexan-2-yl)amino)-4-phenylbutanoyl)-N2-((S)-1-carboxy-3-(phenyl-d5)propyl)-L-lysyl-L-proline

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Chemical Properites
Mol. Formula :
C42H55D5N6O9
Mol. Weight :
798.01
Appearance :
White to Off-white solid
Melting Point :
Not available
For Laboratory research use only, not for drug, household or other uses.

Applications : This is a deuterium labelled version an impurity of Lisinopril (Lisinopril-d5 EP impurity G), which is is an angiotensin-converting enzyme (ACE) inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks, and also in preventing renal and retinal complications of diabetes.

References : Nemoto S. et al.: J. Am Coll Cardiol, 40(1), 149-154, 2002; Swaan P. W. et al.: Biochim Biophys Acta,1236(1), 31-38, 1995; Mantle D. et al.: Clin Chim Acta, 299(1-2), 1-10, 2000; Mohammadi-Karakani A. et al.: Clin Chim Acta, 367(1-2), 170-174, 2006; Duman S. et al.: Int. J. Artif Organs, 28(2), 156-163,2005; Selim Isbir C. et al.: Cell Biochem Funct, 18(2), 85-91,2000.

Storage : Keep container tightly closed under nitrogen or argon and refrigerate for long-term shelf life.

Caution : In case of contact with skin or eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing and gloves.

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